2. Signaling Pathways
  3. GPCR/G Protein
  4. PACAP Receptor

PACAP Receptor

Pituitary adenylyl cyclase activating polypeptide receptor

 
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P0221
    PACAP (1-38), human, ovine, rat
    		99.88%
    PACAP (1-38), human, ovine, rat is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC50s of 4 nM, 2 nM, and 1 nM, respectively.
    PACAP (1-38), human, ovine, rat
  • HY-P0220A
    PACAP (6-38), human, ovine, rat TFA
    		98.72%
    PACAP (6-38), human, ovine, rat TFA is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively.
    PACAP (6-38), human, ovine, rat TFA
  • HY-147557
    PAC1R antagonist 1
    		98.43%
    PAC1R antagonist 1 (compound 3d) is a potent and orally active antagonist of PAC1 receptor. PAC1R antagonist 1 can inhibit pituitary adenylate cyclase-activating polypeptide (PACAP)- and nerve injury-induced allodynia.
    PAC1R antagonist 1
  • HY-133529
    PA-8
    PA-8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP in PAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibits PACAP-induced cAMP elevation with an IC50 of 2 nM.
    PA-8
  • HY-129421
    PA-9
    		99.73%
    PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor antagonist. PA-9 dose dependently inhibits PACAP-induced cAMP elevation with an IC50 of 5.6 nM. PA-9 can be used for the research of neuropathic and/or inflammatory pain.
    PA-9
  • HY-P10768
    Ro 25-1553
    		Agonist
    Ro 25-1553 is a 31 amino acid vasoactive intestinal peptide (VIP) analog, that acts as an agonist for VIP2 receptor (VPAC2 receptor). Ro 25-1553 exhibits a bronchodilator effect in nerve-induced or Carbachol (HY-B1208)-induced tracheal smooth muscle contraction in guinea pig model.
    Ro 25-1553
  • HY-P0176A
    PACAP (1-27), human, ovine, rat TFA
    		99.87%
    PACAP (1-27), human, ovine, rat TFA (PACAP 1-27 TFA) is the N-terminal fragment of PACAP-38, and is a potent PACAP receptor antagonist with IC50s of 3 nM, 2 nM and 5 nM for rat PAC1, rat VPAC1 and human VPAC2, respectively.
    PACAP (1-27), human, ovine, rat TFA
  • HY-P0176
    PACAP (1-27), human, ovine, rat
    		99.79%
    PACAP (1-27), human, ovine, rat (PACAP 1-27) is the N-terminal fragment of PACAP-38, and is a potent PACAP receptor antagonist with IC50s of 3 nM, 2 nM and 5 nM for rat PAC1, rat VPAC1 and human VPAC2, respectively.
    PACAP (1-27), human, ovine, rat
  • HY-P1015
    VIP(Guinea pig)
    		Ligand 98.66%
    VIP Guinea pig (Vasoactive intestinal peptide), a trophic and mitogenic factor, stimulates growth in whole cultured embryos. VIP Guinea pig functions as a simple gastrointestinal hormone and suggest a possible neurotransmitter function.
    VIP(Guinea pig)
  • HY-P4127A
    M65 TFA
    		Inhibitor
    M65 TFA is a deleted peptide of maxadilan (61 a.a.) with deletion of the residues between positions 24 and 42 and is a specific antagonist of PACAP type 1 receptor that inhibits ANP secretion and can be used for relevant researches.
    M65 TFA
  • HY-P2609F
    PACAP (1-38), amide, Biotin-labeled
    		98.92%
    PACAP (1-38), amide, Biotin-labeled is a biological active peptide. (Biotin-labeled HY-P0221)
    PACAP (1-38), amide, Biotin-labeled
  • HY-P0221C
    PACAP (1-38) free acid
    		99.84%
    PACAP (1-38) free acid is an endogenous neuropeptide. PACAP (1-38) free acid potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1.
    PACAP (1-38) free acid
  • HY-P0221A
    PACAP (1-38), human, ovine, rat TFA
    PACAP (1-38), human, ovine, rat TFA is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC50s of 4 nM, 2 nM, and 1 nM, respectively.
    PACAP (1-38), human, ovine, rat TFA
  • HY-P1817
    PACAP-38 (16-38), human, mouse, rat
    PACAP-38 (16-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP is a potent activator of cAMP formation.
    PACAP-38 (16-38), human, mouse, rat
  • HY-P1015A
    VIP(Guinea pig) TFA
    		Ligand
    VIP Guinea pig TFA (Vasoactive intestinal peptide), a trophic and mitogenic factor, stimulates growth in whole cultured embryos. VIP Guinea pig functions as a simple gastrointestinal hormone and suggest a possible neurotransmitter function.
    VIP(Guinea pig) TFA
  • HY-P0221B
    PACAP (1-38) free acid TFA
    PACAP (1-38) free acid TFA is an endogenous neuropeptide. PACAP (1-38) free acid TFA potently stimulates antral motility and somatostatin secretion, inhibits the secretion of gastrin and stimulates the release of vasoactive intestinal polypeptide, gastrin releasing peptide and substance P. PACAP (1-38) free acid TFA also enhances N-methyl-D-aspartate receptor function and expression of brain-derived neurotrophic factor through RACK1.
    PACAP (1-38) free acid TFA
  • HY-P1511
    PACAP-Related Peptide (PRP), human
    PACAP-Related Peptide (PRP), human is a 29 amino-acid region of the PACAP precursor protein.
    PACAP-Related Peptide (PRP), human
  • HY-P3875
    [Arg-15,20,21,Leu17]-PACAP-Gly-Lys-Arg-NH2
    [Arg-15,-20,-21,Leu17]-PACAP-Gly-Lys-Arg-NH2 (BM-PACAP) is a synthetic PACAP 1-27 (HY-P0176) analogue with relaxant effect.
    [Arg-15,20,21,Leu17]-PACAP-Gly-Lys-Arg-NH2
  • HY-125690
    Thielocin B1
    		Inhibitor
    Thielocin B1 is a protein-protein interaction inhibitor of PAC3 homodimer.
    Thielocin B1
  • HY-P0220
    PACAP (6-38), human, ovine, rat
    PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively.
    PACAP (6-38), human, ovine, rat
Cat. No. Product Name / Synonyms Application Reactivity